How https://www.ceesdekker.net can Save You Time, Stress, and Money.
How https://www.ceesdekker.net can Save You Time, Stress, and Money.
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic aspects of the framework and dynamics of chromosomes. Our analysis interests involve:
Human Rad51 filaments on double- and single-stranded DNA: correlating standard and irregular forms with recombination perform.
Back in 1991, Sumio Iijima in the NEC Corporation had noted the synthesis of carbon nanotubes. Band construction calculations advised that these nanotubes could exhibit metallic band conduction. This could be a big edge about the conducting polymers we experienced explored, which have been, the truth is, disordered semiconductors presenting just variable-selection hopping conductivity.
Considering the fact that 2000, Dekker has shifted the key concentration of his work in direction of biophysics where by he experiments the properties of solitary biomolecules and cells using the instruments of nanotechnology. This change of area was driven by his fascination to the extraordinary functioning of biological molecular structures, and also because of the long-phrase viewpoint a large number of attention-grabbing discoveries can be expected On this discipline.[five] Latest strains of exploration in his biophysics team are during the parts of:[six]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initially at any time study of the dynamics DNA supercoils and the invention of supercoil hopping
Direct immobilization of indigenous yeast iso-1 cytochrome c on bare gold: rapid electron relay to redox enzymes and zeptomole protein-film voltammetry
We form germs into forms that deviate from their natural phenotype. Specifically, I'll exhibit our capacity to shape live E. coli germs into novel styles such as rectangles, squares, triangles and circles.
Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial cees dekker chromosome segregation
The rotors harness Electricity from a nanoscale water and ion stream that is certainly generated by a static chemical or electrochemical opportunity gradient while in the nanopore, which can be established by way of a salt gradient or utilized voltage, respectively. These synthetic nanoengines self-Arrange and operate autonomously in physiological ailments, suggesting approaches to constructing Strength-transducing motors at nanoscale interfaces.
Really neat, but that wasn’t actually wherever my interest lay. I wished to pioneer And that i experienced the feeling that was no more probable, because the most intriguing essential insights experienced currently been uncovered. But my area experienced made many fascinating new instruments to measure personal molecules. I decided which i planned to utilize this to biology, to look at it from a physical perspective.’
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2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes